Presymptomatic compensation in Parkinson's disease is not dopamine-mediated
Identifieur interne : 000277 ( France/Analysis ); précédent : 000276; suivant : 000278Presymptomatic compensation in Parkinson's disease is not dopamine-mediated
Auteurs : Erwan Bezard [France] ; Christian E. Gross [France] ; Jonathan M. Brotchie [Canada]Source :
- Trends in neurosciences : (Regular edition) [ 0166-2236 ] ; 2003.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The symptoms of Parkinson's disease (PD) appear only after substantial degeneration of the dopaminergic neuron system (e.g. an 80% depletion of striatal dopamine) - that is, there is a substantive presymptomatic period of the disease. It is widely believed that dopamine-related compensatory mechanisms are responsible for delaying the appearance of symptoms. Recent advances in understanding the presymptomatic phase of PD have increased our understanding of these dopamine-related compensatory mechanisms and have highlighted the role of non-dopamine-mediated mechanisms both within and outside the basal ganglia. This increased knowledge of plasticity within cortical-basal-ganglia-thalamocortical circuitry as dopaminergic neuron degeneration progresses has implications for understanding plasticity in neural circuits generally and, more specifically, for developing novel therapeutics or presymptomatic diagnostics for PD.
Affiliations:
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Pascal:04-0275228Le document en format XML
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Gross</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université Victor Segalen, 146 rue Léo Saignat</s1><s2>33076 Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Brotchie, Jonathan M" sort="Brotchie, Jonathan M" uniqKey="Brotchie J" first="Jonathan M." last="Brotchie">Jonathan M. Brotchie</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Applied and Interventional Research, Toronto Western Research Institute, McLaughlin Wing, Room 11-419, Toronto Western Hospital, 399 Bathurst Street</s1><s2>ON, Toronto, M5T 2S8</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>ON, Toronto, M5T 2S8</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Trends in neurosciences : (Regular edition)</title><title level="j" type="abbreviated">Trends neurosci. : (Regul. ed.)</title><idno type="ISSN">0166-2236</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Trends in neurosciences : (Regular edition)</title><title level="j" type="abbreviated">Trends neurosci. : (Regul. ed.)</title><idno type="ISSN">0166-2236</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Compensation</term><term>Corpus striatum</term><term>Degeneration</term><term>Depletion</term><term>Dopamine</term><term>Dopaminergic neuron</term><term>Parkinson disease</term><term>Plasticity</term><term>Review</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Compensation</term><term>Dopamine</term><term>Dégénérescence</term><term>Neurone dopaminergique</term><term>Déplétion</term><term>Corps strié</term><term>Plasticité</term><term>Article synthèse</term><term>Parkinson maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The symptoms of Parkinson's disease (PD) appear only after substantial degeneration of the dopaminergic neuron system (e.g. an 80% depletion of striatal dopamine) - that is, there is a substantive presymptomatic period of the disease. It is widely believed that dopamine-related compensatory mechanisms are responsible for delaying the appearance of symptoms. Recent advances in understanding the presymptomatic phase of PD have increased our understanding of these dopamine-related compensatory mechanisms and have highlighted the role of non-dopamine-mediated mechanisms both within and outside the basal ganglia. This increased knowledge of plasticity within cortical-basal-ganglia-thalamocortical circuitry as dopaminergic neuron degeneration progresses has implications for understanding plasticity in neural circuits generally and, more specifically, for developing novel therapeutics or presymptomatic diagnostics for PD.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li></settlement></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name></region><name sortKey="Gross, Christian E" sort="Gross, Christian E" uniqKey="Gross C" first="Christian E." last="Gross">Christian E. Gross</name></country><country name="Canada"><noRegion><name sortKey="Brotchie, Jonathan M" sort="Brotchie, Jonathan M" uniqKey="Brotchie J" first="Jonathan M." last="Brotchie">Jonathan M. Brotchie</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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